Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets

Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets

A hallmark of all primary and metastatic tumours is their high rate of glucose uptake and glycolysis. A consequence of the glycolytic phenotype is the accumulation of metabolic acid; hence, tumour cells experience considerable intracellular acid stress. To compensate, tumour cells upregulate acid pu...

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Bibliografske podrobnosti
Main Authors: John J. Shin, Qurratulain Aftab, Pamela Austin, Jennifer A. McQueen, Tak Poon, Shu Chen Li, Barry P. Young, Calvin D. Roskelley, Christopher J. R. Loewen
Format: Article
Jezik:English
Izdano: The Company of Biologists 2016-09-01
Serija:Disease Models & Mechanisms
Teme:
AP-3 complex
Hap1 cells
Mitochondria
PAN complex
Intracellular acid stress
Metabolism
Online dostop:http://dmm.biologists.org/content/9/9/1039

Internet

http://dmm.biologists.org/content/9/9/1039

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