A Novel Cre/lox71-Based System for Inducible Expression of Recombinant Proteins and Genome Editing

A Novel Cre/lox71-Based System for Inducible Expression of Recombinant Proteins and Genome Editing

In this study, we developed a novel Cre/lox71-based system for the controlled transient expression of target genes. We used the bacteriophage P1 Cre recombinase, which harbors a short, highly specific DNA-binding site and does not have endogenous binding sites within mouse or human genomes. Fusing t...

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Bibliographic Details
Main Authors: Maxim Karagyaur, Daniyar Dyikanov, Pyotr Tyurin-Kuzmin, Stalik Dzhauari, Mariya Skryabina, Maksim Vigovskiy, Alexandra Primak, Natalia Kalinina, Vsevolod Tkachuk
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
controlled expression
artificial transcription factor
Cre recombinase
gene therapy
functional genomics
genome editing
Online Access:https://www.mdpi.com/2073-4409/11/14/2141

Internet

https://www.mdpi.com/2073-4409/11/14/2141

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