Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma

Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma

BackgroundThe mitochondrial pyruvate dehydrogenase complex (PDC) link glycolysis to the tricarboxylic acid cycle by decarboxylating pyruvate to acetyl coenzyme A irreversibly. Cancer cells are characterized by a shift in cellular metabolism from mitochondrial respiration to glycolysis. PDC activity...

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Bibliographic Details
Main Authors: Yu-Hsuan Kuo, Ti-Chun Chan, Hong-Yue Lai, Tzu-Ju Chen, Li-Ching Wu, Chung-Hsi Hsing, Chien-Feng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Oncology
Subjects:
pyruvate dehydrogenase kinase-3
urothelial carcinoma of the bladder
urothelial carcinoma of upper urinary tract
cancer metabolism
metabolic reprogramming
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.749142/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.749142/full

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