A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer

A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer

SOX2 amplification and overexpression represents a hallmark of squamous cancers with distinct distribution of chromatin accessible regions depending on cancer type. Here, the authors identify a single enhancer e1 that predominantly drives SOX2 expression in squamous cancer.

Bibliographic Details
Main Authors: Yanli Liu, Zhong Wu, Jin Zhou, Dinesh K. A. Ramadurai, Katelyn L. Mortenson, Estrella Aguilera-Jimenez, Yifei Yan, Xiaojun Yang, Alison M. Taylor, Katherine E. Varley, Jason Gertz, Peter S. Choi, Andrew D. Cherniack, Xingdong Chen, Adam J. Bass, Swneke D. Bailey, Xiaoyang Zhang
Format: Article
Language:English
Published: Nature Portfolio 2021-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-27055-4

Internet

https://doi.org/10.1038/s41467-021-27055-4

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