MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

Abstract Aneuploidy, chromosomal instability, somatic copy-number alterations, and whole-genome doubling (WGD) play key roles in cancer evolution and provide information for the complex task of phylogenetic inference. We present MEDICC2, a method for inferring evolutionary trees and WGD using haplot...

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Bibliographic Details
Main Authors: Tom L. Kaufmann, Marina Petkovic, Thomas B. K. Watkins, Emma C. Colliver, Sofya Laskina, Nisha Thapa, Darlan C. Minussi, Nicholas Navin, Charles Swanton, Peter Van Loo, Kerstin Haase, Maxime Tarabichi, Roland F. Schwarz
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Genome Biology
Subjects:
Somatic copy-number alterations
Chromosomal instability
Aneuploidy
Whole-genome doubling
Intratumor heterogeneity
Cancer evolution
Online Access:https://doi.org/10.1186/s13059-022-02794-9

Internet

https://doi.org/10.1186/s13059-022-02794-9

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