Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics

Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics

The treatment of chronic pain is poorly managed by current analgesics, and there is a need for new classes of drugs. We recently developed a series of bioactive lipids that inhibit the human glycine transporter GlyT2 (SLC6A5) and provide analgesia in animal models of pain. Here, we have used functio...

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Bibliographic Details
Main Authors: Shannon N Mostyn, Katie A Wilson, Alexandra Schumann-Gillett, Zachary J Frangos, Susan Shimmon, Tristan Rawling, Renae M Ryan, Megan L O'Mara, Robert J Vandenberg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
glycine transporter
bioactive lipid
analgesic
allosteric inhibitor
lipid binding site
Online Access:https://elifesciences.org/articles/47150

Internet

https://elifesciences.org/articles/47150

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