Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics
The treatment of chronic pain is poorly managed by current analgesics, and there is a need for new classes of drugs. We recently developed a series of bioactive lipids that inhibit the human glycine transporter GlyT2 (SLC6A5) and provide analgesia in animal models of pain. Here, we have used functio...
Main Authors: | Shannon N Mostyn, Katie A Wilson, Alexandra Schumann-Gillett, Zachary J Frangos, Susan Shimmon, Tristan Rawling, Renae M Ryan, Megan L O'Mara, Robert J Vandenberg |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-10-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/47150 |
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