Catalpol ameliorates CFA-induced inflammatory pain by targeting spinal cord and peripheral inflammation

Catalpol ameliorates CFA-induced inflammatory pain by targeting spinal cord and peripheral inflammation

Chronic, inflammatory pain is an international health concern that severely diminishes individuals’ quality of life. Catalpol is an iridoid glycoside derived from the roots of Rehmannia glutinosa that possesses anti-inflammatory, antioxidant, and neuroprotective properties for the treating multiple...

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Bibliographic Details
Main Authors: Baoxia Zhao, Jie Fu, Huadong Ni, Longsheng Xu, Chengfei Xu, Qiuli He, Chaobo Ni, Yahui Wang, Jiao Kuang, Mengjie Tang, Qiyang Shou, Ming Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
catalpol
inflammatory pain
HDAC4/PPAR-γ -signaling pathway
NF-κB/NLRP3 inflammatory axis
astrocyte activation
peripheral pain
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1010483/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.1010483/full

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