Novel PD-L1-Targeted Phenyl-Pyrazolone Derivatives with Antioxidant Properties

Novel PD-L1-Targeted Phenyl-Pyrazolone Derivatives with Antioxidant Properties

Orally-active anticancer small molecules targeting the PD-1/PD-L1 immune checkpoint are actively searched. Phenyl-pyrazolone derivatives with a high affinity for PD-L1 have been designed and characterized. In addition, the phenyl-pyrazolone unit acts as a scavenger of oxygen free radicals, providing...

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Bibliographic Details
Main Authors: Romain Regnault, Frédérique Klupsch, Hassiba El-Bouazzati, Romain Magnez, Raphaël Le Biannic, Natascha Leleu-Chavain, Hania Ahouari, Hervé Vezin, Régis Millet, Jean-François Goossens, Xavier Thuru, Christian Bailly
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Molecules
Subjects:
aldehyde reactivity
antioxidant
cancer
immune checkpoint
PD-L1 binding
pyrazolone
Online Access:https://www.mdpi.com/1420-3049/28/8/3491

Internet

https://www.mdpi.com/1420-3049/28/8/3491

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