Selective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged mice

Abstract Adenylyl cyclase 1 (AC1) is a selective subtype of ACs, which is selectively expressed in neurons. The activation of AC1 is activity-dependent, and AC1 plays an important role in cortical excitation that contributes to chronic pain and related emotional disorders. Previous studies have repo...

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Bibliographic Details
Main Authors: Wantong Shi, Qi-Yu Chen, Yujie Ma, Jinjin Wan, Xu-Hui Li, Min Zhuo
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Molecular Brain
Subjects:
Online Access:https://doi.org/10.1186/s13041-024-01083-9