Synthesis and Evaluation of the Tetracyclic Ring-System of Isocryptolepine and Regioisomers for Antimalarial, Antiproliferative and Antimicrobial Activities

Synthesis and Evaluation of the Tetracyclic Ring-System of Isocryptolepine and Regioisomers for Antimalarial, Antiproliferative and Antimicrobial Activities

A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel hydroiodide salts <b>10</b> and <b>21</b> showed the most promising antiplasmodial inhibition...

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Bibliographic Details
Main Authors: Katja S. Håheim, Emil Lindbäck, Kah Ni Tan, Marte Albrigtsen, Ida T. Urdal Helgeland, Clémence Lauga, Théodora Matringe, Emily K. Kennedy, Jeanette H. Andersen, Vicky M. Avery, Magne O. Sydnes
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
indoloquinoline
antiplasmodial activity
antiproliferative activity
antimicrobial activity
biofilm inhibition
Online Access:https://www.mdpi.com/1420-3049/26/11/3268

Internet

https://www.mdpi.com/1420-3049/26/11/3268

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