Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1

Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1

Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct cause-effect relationships are not well understood. We show that most yeast cells arrest in G1 before death with low nuclear levels of Cln3, a key G1 cyclin extremely sensitive to chaperone status. Chaperone availabi...

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Bibliographic Details
Main Authors: David F Moreno, Kirsten Jenkins, Sandrine Morlot, Gilles Charvin, Attila Csikasz-Nagy, Martí Aldea
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
aging
proteostasis
proliferation
Start
chaperone
G1 cyclin
Online Access:https://elifesciences.org/articles/48240

Internet

https://elifesciences.org/articles/48240

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