Primary cilia suppress Ripk3-mediated necroptosis

Abstract Cilia are sensory organelles that project from the surface of almost all cells. Nephronophthisis (NPH) and NPH-related ciliopathies are degenerative genetic diseases caused by mutation of cilia-associated genes. These kidney disorders are characterized by progressive loss of functional tubu...

Full description

Bibliographic Details
Main Authors: Emilia Kieckhöfer, Gisela G. Slaats, Lena K. Ebert, Marie-Christine Albert, Claudia Dafinger, Hamid Kashkar, Thomas Benzing, Bernhard Schermer
Format: Article
Language:English
Published: Nature Publishing Group 2022-12-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-01272-2