Oxaliplatin-induced peripheral neurotoxicity in colorectal cancer patients: mechanisms, pharmacokinetics and strategies

Oxaliplatin-induced peripheral neurotoxicity in colorectal cancer patients: mechanisms, pharmacokinetics and strategies

Oxaliplatin-based chemotherapy is a standard treatment approach for colorectal cancer (CRC). However, oxaliplatin-induced peripheral neurotoxicity (OIPN) is a severe dose-limiting clinical problem that might lead to treatment interruption. This neuropathy may be reversible after treatment discontinu...

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Bibliographic Details
Main Authors: Fang Cheng, Ruoqi Zhang, Chen Sun, Qian Ran, Cuihan Zhang, Changhong Shen, Ziqing Yao, Miao Wang, Lin Song, Cheng Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Pharmacology
Subjects:
oxaliplatin
peripheral neurotoxicity
colorectal cancer
adverse reaction
mechanism
pharmacokinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1231401/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1231401/full

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