The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer

The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer

Abstract AXL is a receptor tyrosine kinase that is often overexpressed in cancers. It contributes to pathophysiology in cancer progression and therapeutic resistance, making it an emerging therapeutic target. The first-in-class AXL inhibitor bemcentinib (R428/BGB324) has been granted fast track desi...

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Bibliographic Details
Main Authors: Xun Hui Yeo, Vignesh Sundararajan, Zhengwei Wu, Zi Jin Cheryl Phua, Yin Ying Ho, Kai Lay Esther Peh, Yi-Chia Chiu, Tuan Zea Tan, Dennis Kappei, Ying Swan Ho, David Shao Peng Tan, Wai Leong Tam, Ruby Yun-Ju Huang
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05045-0

Internet

https://doi.org/10.1038/s42003-023-05045-0

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