Intra-articular delivery of an indoleamine 2,3-dioxygenase galectin-3 fusion protein for osteoarthritis treatment in male Lewis rats

Intra-articular delivery of an indoleamine 2,3-dioxygenase galectin-3 fusion protein for osteoarthritis treatment in male Lewis rats

Abstract Objective Osteoarthritis (OA) is driven by low-grade inflammation, and controlling local inflammation may offer symptomatic relief. Here, we developed an indoleamine 2,3-dioxygenase and galectin-3 fusion protein (IDO-Gal3), where IDO increases the production of local anti-inflammatory metab...

Full description

Bibliographic Details
Main Authors: Brittany D. Partain, Evelyn Bracho-Sanchez, Shaheen A. Farhadi, Elena G. Yarmola, Benjamin G. Keselowsky, Gregory A. Hudalla, Kyle D. Allen
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Arthritis Research & Therapy
Subjects:
Knee osteoarthritis
Indoleamine 2,3-dioxygenase
Galectin-3
Metabolic reprogramming
Intra-articular drug delivery
Inflammation
Online Access:https://doi.org/10.1186/s13075-023-03153-0

Internet

https://doi.org/10.1186/s13075-023-03153-0

Similar Items