Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD

Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD

Abstract There is an intrinsic relationship between psychiatric disorders and neuroinflammation, including bipolar disorder. Ouabain, an inhibitor of Na+/K+-ATPase, has been implicated in the mouse model with manic-like behavior. However, the molecular mechanisms linking neuroinflammation and manic-...

Full description

Bibliographic Details
Main Authors: Tzu-Yun Wang, Eddie Feng-Ju Weng, Yun-Chen Hsu, Lu-Ping Shiu, Teng-Wei Huang, Hsuan-Cheng Wu, Jau-Shyong Hong, Shao-Ming Wang
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Bipolar disease
Ouabain-induced manic-like behavior
CEBPD
MMP8
Online Access:https://doi.org/10.1186/s12974-024-03054-2

Internet

https://doi.org/10.1186/s12974-024-03054-2

Similar Items