Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader

Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader

Abstract Aldo-keto reductase 1C3 (AKR1C3) is a protein upregulated in prostate cancer, hematological malignancies, and other cancers where it contributes to proliferation and chemotherapeutic resistance. Androgen receptor splice variant 7 (ARv7) is the most common mutation of the AR receptor that co...

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Bibliographic Details
Main Authors: Angelica V. Carmona, Shirisha Jonnalagadda, Alfie M. Case, Krishnaiah Maddeboina, Sravan K. Jonnalagadda, Louise F. Dow, Ling Duan, Trevor M. Penning, Paul C. Trippier
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-024-01177-4

Internet

https://doi.org/10.1038/s42004-024-01177-4

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