Improper preanalytical processes on peripheral blood compromise RNA quality and skew the transcriptional readouts of mRNA and LncRNA

Improper preanalytical processes on peripheral blood compromise RNA quality and skew the transcriptional readouts of mRNA and LncRNA

Genetic and epigenetic reprogramming caused by disease states in other tissues is always systemically reflected in peripheral blood leukocytes (PBLs). Accurate transcriptional readouts of Messenger RNA (mRNA) and Long non-coding RNA (lncRNA) in peripheral blood leukocytes are fundamental for disease...

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Bibliographic Details
Main Authors: Yinli He, Lele Dong, Hongyang Yi, Linpei Zhang, Xue Shi, Lin Su, Baoyu Gan, Ruirui Guo, Yawen Wang, Qinying Luo, Xiaojiao Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Genetics
Subjects:
peripheral blood leukocytes (PBLs)
preanalytical processes
RNA quality
transcriptional readouts
COPD
TNBC
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.1091685/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.1091685/full

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