Association of Plasma Claudin-5 with Age and Alzheimer Disease

Association of Plasma Claudin-5 with Age and Alzheimer Disease

The blood–brain barrier (BBB) plays pivotal roles in synaptic and neuronal functioning by sealing the space between adjacent microvascular endothelial cells. BBB breakdown is present in patients with mild cognitive impairment (MCI) or Alzheimer disease (AD). Claudin-5 (CLDN-5) is a tetra-spanning pr...

Full description

Bibliographic Details
Main Authors:	Keisuke Tachibana, Ryuichi Hirayama, Naoyuki Sato, Kotaro Hattori, Takashi Kato, Hiroyuki Takeda, Masuo Kondoh
Format:	Article
Language:	English
Published:	MDPI AG 2024-01-01
Series:	International Journal of Molecular Sciences
Subjects:	blood–brain barrier claudin-5 tight junction biomarker dementia Alzheimer disease
Online Access:	https://www.mdpi.com/1422-0067/25/3/1419

Similar Items

Claudin-4: A New Molecular Target for Epithelial Cancer Therapy
by: Rina Fujiwara-Tani, et al.
Published: (2023-03-01)

Intestinal Barrier, Claudins and Mycotoxins
by: Marta Justyna Kozieł, et al.
Published: (2021-10-01)

The Expression and Localization of ZO-1, Claudin 1, and Claudin 4 in the Pig Epididymis
by: Yun-Jae Park, et al.
Published: (2019-09-01)

Reconstitution of functional tight junctions with individual claudin subtypes in epithelial cells
by: Mikio Furuse, et al.
Published: (2022-12-01)

Prednisolone Targets Claudins in Mouse Brain Blood Vessels
by: Alexander G. Markov, et al.
Published: (2023-12-01)

Quercetin increases claudin-4 expression through multiple transcription factors in intestinal Caco-2 cells
by: Sakino Noda, et al.
Published: (2014-09-01)

Claudins: New Players in Human Fertility and Reproductive System Cancers
by: Marta Justyna Kozieł, et al.
Published: (2020-03-01)

Claudin Loss-of-Function Disrupts Tight Junctions and Impairs Amelogenesis
by: Claire Bardet, et al.
Published: (2017-05-01)

Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review
by: Keisuke Tachibana, et al.
Published: (2020-12-01)

Barrier Perturbation in Porcine Peyer’s Patches by Tumor Necrosis Factor is Associated With a Dysregulation of Claudins
by: Linda Droessler, et al.
Published: (2022-05-01)

RETRACTED ARTICLE: Differences in the expression profiles of claudin proteins in human nasopharyngeal carcinoma compared with non-neoplastic mucosa
by: Xiaowei Zhang, et al.
Published: (2018-02-01)

Claudin-12 is not required for blood–brain barrier tight junction function
by: Mariana Castro Dias, et al.
Published: (2019-09-01)

Prognostic Significance of Aberrant Claudin-6 Expression in Endometrial Cancer
by: Manabu Kojima, et al.
Published: (2020-09-01)

Disheveled-1 Interacts with Claudin-5 and Contributes to Norrin-Induced Endothelial Barrier Restoration
by: Mónica Díaz-Coránguez, et al.
Published: (2023-10-01)

Claudin Barriers on the Brink: How Conflicting Tissue and Cellular Priorities Drive IBD Pathogenesis
by: Christopher T. Capaldo
Published: (2023-05-01)

miR-195-5p Regulates Tight Junctions Expression via Claudin-2 Downregulation in Ulcerative Colitis
by: Viviana Scalavino, et al.
Published: (2022-04-01)

On the Interaction of Clostridium perfringens Enterotoxin with Claudins
by: Anna Veshnyakova, et al.
Published: (2010-06-01)

Claudin-1, -2 and -3 are selectively expressed in the epithelia of the choroid plexus of the mouse from early development and into adulthood while claudin-5 is restricted to endothelial cells
by: Alexandra eSteinemann, et al.
Published: (2016-02-01)

Computational Models of Claudin Assembly in Tight Junctions and Strand Properties
by: Sarah McGuinness, et al.
Published: (2024-03-01)

Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier
by: Yanyu Li, et al.
Published: (2022-06-01)

Expression and localization of claudins-3 and -12 in transformed human brain endothelium
by: Schrade Anja, et al.
Published: (2012-02-01)

A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5
by: Lisanne Martine van Leeuwen, et al.
Published: (2018-02-01)

5,7-Dimethoxyflavone enhances barrier function by increasing occludin and reducing claudin-2 in human intestinal Caco-2 cells
by: Yunika Mayangsari, et al.
Published: (2021-10-01)

Chimeric Claudins: A New Tool to Study Tight Junction Structure and Function
by: Abigail Taylor, et al.
Published: (2021-05-01)

Blood-Brain Barrier Protein Claudin-5 Expressed in Paired Xenopus laevis Oocytes Mediates Cell-Cell Interaction
by: Nora Brunner, et al.
Published: (2020-07-01)

N-acetylcysteine decreases airway inflammation and responsiveness in asthma by modulating claudin 18 expression
by: Pureun-Haneul Lee, et al.
Published: (2020-09-01)

Molecular Characterization of Barrier Properties in Follicle-Associated Epithelium of Porcine Peyer's Patches Reveals Major Sealing Function of Claudin-4
by: Judith Radloff, et al.
Published: (2017-08-01)

Barriers and channels formed by tight junction proteins II /
by: Fromm, Michael, et al.
Published: (2012)

Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injury
by: Alejandro E. Garcia-Flores, et al.
Published: (2022-12-01)

Claudin-11 in health and disease: implications for myelin disorders, hearing, and fertility
by: Sophia C. Gjervan, et al.
Published: (2024-01-01)

Intestinal Claudin-7 deficiency impacts the intestinal microbiota in mice with colitis
by: Yuhan Ding, et al.
Published: (2022-01-01)

Emerging clinical significance of claudin-7 in colorectal cancer: a review
by: Wang K, et al.
Published: (2018-09-01)

Expression of the kidney anion exchanger 1 affects WNK4 and SPAK phosphorylation and results in claudin-4 phosphorylation
by: Rawad Lashhab, et al.
Published: (2023-11-01)

Reduced Claudin-12 Expression Predicts Poor Prognosis in Cervical Cancer
by: Abidur Rahman, et al.
Published: (2021-04-01)

Claudin-4-adhesion signaling drives breast cancer metabolism and progression via liver X receptor β
by: Yuko Murakami-Nishimagi, et al.
Published: (2023-04-01)

Epithelial Barrier Dysfunction in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) via Downregulation of Claudin-1
by: Karem Awad, et al.
Published: (2023-12-01)

Expression Patterns of Claudin Family Members During Tooth Development and the Role of Claudin-10 (Cldn10) in Cytodifferentiation of Stratum Intermedium
by: Xin Wang, et al.
Published: (2020-10-01)

Myrrh protects against IL-13-induced epithelial barrier breakdown in HT-29/B6 cells
by: Helena Hader, et al.
Published: (2023-11-01)

Hypomethylation of <i>CLDN4</i> Gene Promoter Is Associated with Malignant Phenotype in Urinary Bladder Cancer
by: Fumisato Maesaka, et al.
Published: (2022-06-01)

cCPE Fusion Proteins as Molecular Probes to Detect Claudins and Tight Junction Dysregulation in Gastrointestinal Cell Lines, Tissue Explants and Patient-Derived Organoids
by: Ayk Waldow, et al.
Published: (2023-07-01)