New insights into MAIT cells in autoimmune diseases
Mucosal-associated invariant T (MAIT) cells are resident T cells that express semi-invariant TCR chains and are restricted by monomorphic major histocompatibility complex (MHC) class I-related molecules (MR1). MAIT cells can be activated by microbial-specific metabolites (MR1-dependent mode) or cyto...
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Elsevier
2023-03-01
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Series: | Biomedicine & Pharmacotherapy |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223000380 |
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author | Qi Fan He Nan Zhe Li Bingtong Li Fangze Zhang Liqi Bi |
author_facet | Qi Fan He Nan Zhe Li Bingtong Li Fangze Zhang Liqi Bi |
author_sort | Qi Fan |
collection | DOAJ |
description | Mucosal-associated invariant T (MAIT) cells are resident T cells that express semi-invariant TCR chains and are restricted by monomorphic major histocompatibility complex (MHC) class I-related molecules (MR1). MAIT cells can be activated by microbial-specific metabolites (MR1-dependent mode) or cytokines (MR1-independent mode). Activated MAIT cells produce chemokines, cytotoxic molecules (granzyme B and perforin), and proinflammatory cytokines (IFN-γ, TNF-α, and IL-17), to clear pathogens and target infected cells involved in the pro-inflammatory, migratory, and cytolytic properties of MAIT cells. MAIT cells produce pro-inflammatory cytokines in the target organs of autoimmune diseases and contribute to the development and progression of autoimmune diseases. This article reviews the biological characteristics, activation mechanism, dynamic migration, and dual functions of MAIT cells, and focuses on the mechanism and potential application of MAIT cells in the early diagnosis, disease activity monitoring, and therapeutic targets of autoimmune diseases, to lay a foundation for future research. |
first_indexed | 2024-04-10T17:27:33Z |
format | Article |
id | doaj.art-e4d14e41bd194ae4a1382d0a3e732073 |
institution | Directory Open Access Journal |
issn | 0753-3322 |
language | English |
last_indexed | 2024-04-10T17:27:33Z |
publishDate | 2023-03-01 |
publisher | Elsevier |
record_format | Article |
series | Biomedicine & Pharmacotherapy |
spelling | doaj.art-e4d14e41bd194ae4a1382d0a3e7320732023-02-04T04:17:11ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-03-01159114250New insights into MAIT cells in autoimmune diseasesQi Fan0He Nan1Zhe Li2Bingtong Li3Fangze Zhang4Liqi Bi5Department of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, PR ChinaDepartment of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, PR ChinaDepartment of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, PR ChinaDepartment of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, PR ChinaDepartment of Gastroenterology/Endoscopy Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin, PR China; Co-corresponding authors.Department of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, PR China; Co-corresponding authors.Mucosal-associated invariant T (MAIT) cells are resident T cells that express semi-invariant TCR chains and are restricted by monomorphic major histocompatibility complex (MHC) class I-related molecules (MR1). MAIT cells can be activated by microbial-specific metabolites (MR1-dependent mode) or cytokines (MR1-independent mode). Activated MAIT cells produce chemokines, cytotoxic molecules (granzyme B and perforin), and proinflammatory cytokines (IFN-γ, TNF-α, and IL-17), to clear pathogens and target infected cells involved in the pro-inflammatory, migratory, and cytolytic properties of MAIT cells. MAIT cells produce pro-inflammatory cytokines in the target organs of autoimmune diseases and contribute to the development and progression of autoimmune diseases. This article reviews the biological characteristics, activation mechanism, dynamic migration, and dual functions of MAIT cells, and focuses on the mechanism and potential application of MAIT cells in the early diagnosis, disease activity monitoring, and therapeutic targets of autoimmune diseases, to lay a foundation for future research.http://www.sciencedirect.com/science/article/pii/S0753332223000380Mucosal-associated invariant T cellDual functionsActivation mechanismsAutoimmune diseasesProinflammation |
spellingShingle | Qi Fan He Nan Zhe Li Bingtong Li Fangze Zhang Liqi Bi New insights into MAIT cells in autoimmune diseases Biomedicine & Pharmacotherapy Mucosal-associated invariant T cell Dual functions Activation mechanisms Autoimmune diseases Proinflammation |
title | New insights into MAIT cells in autoimmune diseases |
title_full | New insights into MAIT cells in autoimmune diseases |
title_fullStr | New insights into MAIT cells in autoimmune diseases |
title_full_unstemmed | New insights into MAIT cells in autoimmune diseases |
title_short | New insights into MAIT cells in autoimmune diseases |
title_sort | new insights into mait cells in autoimmune diseases |
topic | Mucosal-associated invariant T cell Dual functions Activation mechanisms Autoimmune diseases Proinflammation |
url | http://www.sciencedirect.com/science/article/pii/S0753332223000380 |
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