New insights into MAIT cells in autoimmune diseases

Mucosal-associated invariant T (MAIT) cells are resident T cells that express semi-invariant TCR chains and are restricted by monomorphic major histocompatibility complex (MHC) class I-related molecules (MR1). MAIT cells can be activated by microbial-specific metabolites (MR1-dependent mode) or cyto...

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Main Authors: Qi Fan, He Nan, Zhe Li, Bingtong Li, Fangze Zhang, Liqi Bi
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223000380
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author Qi Fan
He Nan
Zhe Li
Bingtong Li
Fangze Zhang
Liqi Bi
author_facet Qi Fan
He Nan
Zhe Li
Bingtong Li
Fangze Zhang
Liqi Bi
author_sort Qi Fan
collection DOAJ
description Mucosal-associated invariant T (MAIT) cells are resident T cells that express semi-invariant TCR chains and are restricted by monomorphic major histocompatibility complex (MHC) class I-related molecules (MR1). MAIT cells can be activated by microbial-specific metabolites (MR1-dependent mode) or cytokines (MR1-independent mode). Activated MAIT cells produce chemokines, cytotoxic molecules (granzyme B and perforin), and proinflammatory cytokines (IFN-γ, TNF-α, and IL-17), to clear pathogens and target infected cells involved in the pro-inflammatory, migratory, and cytolytic properties of MAIT cells. MAIT cells produce pro-inflammatory cytokines in the target organs of autoimmune diseases and contribute to the development and progression of autoimmune diseases. This article reviews the biological characteristics, activation mechanism, dynamic migration, and dual functions of MAIT cells, and focuses on the mechanism and potential application of MAIT cells in the early diagnosis, disease activity monitoring, and therapeutic targets of autoimmune diseases, to lay a foundation for future research.
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spelling doaj.art-e4d14e41bd194ae4a1382d0a3e7320732023-02-04T04:17:11ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-03-01159114250New insights into MAIT cells in autoimmune diseasesQi Fan0He Nan1Zhe Li2Bingtong Li3Fangze Zhang4Liqi Bi5Department of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, PR ChinaDepartment of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, PR ChinaDepartment of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, PR ChinaDepartment of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, PR ChinaDepartment of Gastroenterology/Endoscopy Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin, PR China; Co-corresponding authors.Department of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, PR China; Co-corresponding authors.Mucosal-associated invariant T (MAIT) cells are resident T cells that express semi-invariant TCR chains and are restricted by monomorphic major histocompatibility complex (MHC) class I-related molecules (MR1). MAIT cells can be activated by microbial-specific metabolites (MR1-dependent mode) or cytokines (MR1-independent mode). Activated MAIT cells produce chemokines, cytotoxic molecules (granzyme B and perforin), and proinflammatory cytokines (IFN-γ, TNF-α, and IL-17), to clear pathogens and target infected cells involved in the pro-inflammatory, migratory, and cytolytic properties of MAIT cells. MAIT cells produce pro-inflammatory cytokines in the target organs of autoimmune diseases and contribute to the development and progression of autoimmune diseases. This article reviews the biological characteristics, activation mechanism, dynamic migration, and dual functions of MAIT cells, and focuses on the mechanism and potential application of MAIT cells in the early diagnosis, disease activity monitoring, and therapeutic targets of autoimmune diseases, to lay a foundation for future research.http://www.sciencedirect.com/science/article/pii/S0753332223000380Mucosal-associated invariant T cellDual functionsActivation mechanismsAutoimmune diseasesProinflammation
spellingShingle Qi Fan
He Nan
Zhe Li
Bingtong Li
Fangze Zhang
Liqi Bi
New insights into MAIT cells in autoimmune diseases
Biomedicine & Pharmacotherapy
Mucosal-associated invariant T cell
Dual functions
Activation mechanisms
Autoimmune diseases
Proinflammation
title New insights into MAIT cells in autoimmune diseases
title_full New insights into MAIT cells in autoimmune diseases
title_fullStr New insights into MAIT cells in autoimmune diseases
title_full_unstemmed New insights into MAIT cells in autoimmune diseases
title_short New insights into MAIT cells in autoimmune diseases
title_sort new insights into mait cells in autoimmune diseases
topic Mucosal-associated invariant T cell
Dual functions
Activation mechanisms
Autoimmune diseases
Proinflammation
url http://www.sciencedirect.com/science/article/pii/S0753332223000380
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AT fangzezhang newinsightsintomaitcellsinautoimmunediseases
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