A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetesResearch in context

A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetesResearch in context

Summary: Background: Stress responses within the β cell have been linked with both increased β cell death and accelerated immune activation in type 1 diabetes (T1D). At present, information on the timing and scope of these responses as well as disease-related changes in islet β cell protein express...

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Bibliographic Details
Main Authors: Farooq Syed, Divya Singhal, Koen Raedschelders, Preethi Krishnan, Robert N. Bone, Madeline R. McLaughlin, Jennifer E. Van Eyk, Raghavendra G. Mirmira, Mei-Ling Yang, Mark J. Mamula, Huanmei Wu, Xiaowen Liu, Carmella Evans-Molina
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:EBioMedicine
Subjects:
β Cell stress
Type 1 diabetes
Protein disulphide isomerase A1
Proteomics
Biomarkers
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422005618

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http://www.sciencedirect.com/science/article/pii/S2352396422005618

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