Evidence for interaction of the NLRP3 inflammasome and Bruton’s tyrosine kinase in tumor-associated macrophages: implications for myeloid cell production of interleukin-1beta

Evidence for interaction of the NLRP3 inflammasome and Bruton’s tyrosine kinase in tumor-associated macrophages: implications for myeloid cell production of interleukin-1beta

An inflammatory microenvironment has been shown to play an important role in the growth and metastasis of tumors. The NLRP3 inflammasome is a multi-protein complex of the innate immune system that is responsible for the production of the potent inflammatory cytokine IL-1β. Tumor- associated macropha...

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Bibliographic Details
Main Authors: Brooke Benner, Luke Scarberry, Andrew Stiff, Megan C. Duggan, Logan Good, Gabriella Lapurga, Jonathan P. Butchar, Susheela Tridandapani, William E. Carson
Format: Article
Language:English
Published: Taylor & Francis Group 2019-11-01
Series:OncoImmunology
Subjects:
tumor-associated macrophage
il-1b
nlrp3 inflammasome
caspase-1
asc
immunotherapy
cancer
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1659704

Internet

http://dx.doi.org/10.1080/2162402X.2019.1659704

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