HIV infected CD4+ T cell clones are more stable than uninfected clones during long-term antiretroviral therapy.

HIV infected CD4+ T cell clones are more stable than uninfected clones during long-term antiretroviral therapy.

Although combination antiretroviral therapy (ART) blocks HIV replication, it is not curative because infected CD4+ T cells that carry intact, infectious proviruses persist. Understanding the behavior of clones of infected T cells is important for understanding the stability of the reservoir; however...

Full description

Bibliographic Details
Main Authors: Shuang Guo, Brian T Luke, Amy R Henry, Samuel Darko, Leah D Brandt, Ling Su, David Sun, Daria Wells, Kevin W Joseph, Dimiter Demirov, Elias K Halvas, Daniel C Douek, Xiaolin Wu, John W Mellors, Stephen H Hughes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010726

Internet

https://doi.org/10.1371/journal.ppat.1010726

Similar Items