Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease

Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease

Abstract Background In patients with Parkinson’s disease (PD), real-time quaking-induced conversion (RT-QuIC) detection of pathological α-synuclein (α-syn) in olfactory mucosa (OM) is not as accurate as in other α-synucleinopathies. It is unknown whether these variable results might be related to a...

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Bibliographic Details
Main Authors: Matilde Bongianni, Mauro Catalan, Daniela Perra, Elena Fontana, Francesco Janes, Claudio Bertolotti, Luca Sacchetto, Stefano Capaldi, Matteo Tagliapietra, Paola Polverino, Valentina Tommasini, Giulia Bellavita, Elham Ataie Kachoie, Roberto Baruca, Andrea Bernardini, Mariarosaria Valente, Michele Fiorini, Erika Bronzato, Stefano Tamburin, Laura Bertolasi, Lorenzo Brozzetti, Maria Paola Cecchini, Gianluigi Gigli, Salvatore Monaco, Paolo Manganotti, Gianluigi Zanusso
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Translational Neurodegeneration
Subjects:
Parkinson disease
Alpha-synuclein
Real-time quaking-induced conversion assay
Olfactory mucosa
Cerebrospinal fluid
Online Access:https://doi.org/10.1186/s40035-022-00311-3

Internet

https://doi.org/10.1186/s40035-022-00311-3

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