Regulation of Derlin-1-mediated degradation of NADPH oxidase partner p22phox by thiol modification

The transmembrane protein p22phox heterodimerizes with NADPH oxidase (Nox) 1–4 and is essential for the reactive oxygen species-producing capacity of oxidases. Missense mutations in the p22phox gene prevent the formation of phagocytic Nox2-based oxidase, which contributes to host defense. This resul...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Kei Miyano, Shuichiro Okamoto, Mizuho Kajikawa, Takuya Kiyohara, Chikage Kawai, Akira Yamauchi, Futoshi Kuribayashi
Format: Artikel
Sprache:English
Veröffentlicht: Elsevier 2022-10-01
Schriftenreihe:Redox Biology
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Online Zugang:http://www.sciencedirect.com/science/article/pii/S2213231722002518