Intranasally administered extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells quickly incorporate into neurons and microglia in 5xFAD mice

Intranasally administered extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells quickly incorporate into neurons and microglia in 5xFAD mice

IntroductionExtracellular vesicles (EVs) released by human-induced pluripotent stem cell (hiPSC)-derived neural stem cells (NSCs) have robust antiinflammatory and neurogenic properties due to therapeutic miRNAs and proteins in their cargo. Hence, hiPSC-NSC-EVs are potentially an excellent biologic f...

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Sahithi Attaluri, Jenny Jaimes Gonzalez, Maha Kirmani, Andrew D. Vogel, Raghavendra Upadhya, Maheedhar Kodali, Leelavathi N. Madhu, Shama Rao, Bing Shuai, Roshni S. Babu, Charles Huard, Ashok K. Shetty
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: Frontiers Media S.A. 2023-06-01
Sraith:Frontiers in Aging Neuroscience
Ábhair:
Alzheimer’s disease
astrocytes
extracellular vesicles
human neural stem cells
human pluripotent stem cells
interstitial space
Rochtain ar líne:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1200445/full

Ar líne

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1200445/full

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