Resistência ao tratamento no linfoma de Burkitt: associação com mutações específicas no gene TP53? Treatment resistance in Burkitt's lymphoma: is it associated with specific mutations of the TP53 gene?

Resistência ao tratamento no linfoma de Burkitt: associação com mutações específicas no gene TP53? Treatment resistance in Burkitt's lymphoma: is it associated with specific mutations of the TP53 gene?

O linfoma de Burkitt (LB) surge a partir de uma célula do centro germinativo que perde o controle da proliferação devido à ativação do gene c-myc. A resistência à apoptose é uma causa importante da falha à quimioterapia na maioria dos cânceres e também no LB. A taxa alta de apoptose observada no LB...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Eliane P. S. Magluta, Claudete E. Klumb
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	Elsevier 2008-02-01
Cyfres:	Revista Brasileira de Hematologia e Hemoterapia
Pynciau:	Linfoma de Burkitt gene TP53 mutação resistência tratamento Burkitt's lymphoma TP53 gene mutation resistance treatment
Mynediad Ar-lein:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000100011

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