2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione isolated from Averrhoa carambola L. root inhibits high glucose-induced EMT in HK-2 cells through targeting the regulation of miR-21–5p/Smad7 signaling pathway

2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione isolated from Averrhoa carambola L. root inhibits high glucose-induced EMT in HK-2 cells through targeting the regulation of miR-21–5p/Smad7 signaling pathway

Objective: 2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione (DMDD) isolated from Averrhoa carambola L. root, has been proven therapeutic effects on diabetic kidney disease (DKD). This research aims to assess DMDD’s effects on DKD and to investigate its underlying mechanisms, to establish DMDD as a...

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Bibliographic Details
Main Authors: Jingyi Li, Qiuling Pang, Xiaoman Huang, Huixian Jiang, Ganling Tang, Hui Yan, Yanxiang Guo, Xiaoyi Yan, Lang Li, Hongliang Zhang
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
DMDD
Diabetic kidney disease
Epithelial-mesenchymal transition
MiR-21–5p
Smad7
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224001616

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http://www.sciencedirect.com/science/article/pii/S0753332224001616

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