Etoposide-Induced Apoptosis in Cancer Cells Can Be Reinforced by an Uncoupled Link between Hsp70 and Caspase-3

Etoposide-Induced Apoptosis in Cancer Cells Can Be Reinforced by an Uncoupled Link between Hsp70 and Caspase-3

The Hsp70 chaperone binds and inhibits proteins implicated in apoptotic signaling including Caspase-3. Induction of apoptosis is an important mechanism of anti-cancer drugs, therefore Hsp70 can act as a protective system in tumor cells against therapeutic agents. In this study we present an assessme...

Full description

Bibliographic Details
Main Authors: Dmitry V. Sverchinsky, Alina D. Nikotina, Elena Y. Komarova, Elena R. Mikhaylova, Nikolay D. Aksenov, Vladimir F. Lazarev, Vladimir A. Mitkevich, Roman Suezov, Dmitry S. Druzhilovskiy, Vladimir V. Poroikov, Boris A. Margulis, Irina V. Guzhova
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
Hsp70
Caspase-3
apoptosis
anti-cancer drugs
biological activity prediction
PASS
Online Access:http://www.mdpi.com/1422-0067/19/9/2519

Internet

http://www.mdpi.com/1422-0067/19/9/2519

Similar Items