The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse model

The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse model

Abstract Background Microdeletion of the human chromosomal region 16p11.2 (16p11.2 $${}^{+/-}$$ + / - ) is a prevalent genetic factor associated with autism spectrum disorder (ASD) and other neurodevelopmental disorders. However its pathogenic mechanism remains unclear, and effective treatments for...

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Podrobná bibliografie
Hlavní autoři: Jian Jiang, Dilong Wang, Youheng Jiang, Xiuyan Yang, Runfeng Sun, Jinlong Chang, Wenhui Zhu, Peijia Yao, Kun Song, Shuwen Chang, Hong Wang, Lei Zhou, Xue-Song Zhang, Huiliang Li, Ningning Li
Médium: Článek
Jazyk:English
Vydáno: BMC 2024-03-01
Edice:Microbiome
Témata:
Autism
Social deficits
Gut microbiota metabolite
Indole-3-propionic acid
Mapk3
GABA
On-line přístup:https://doi.org/10.1186/s40168-024-01755-7

Internet

https://doi.org/10.1186/s40168-024-01755-7

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