A robust deep learning workflow to predict CD8 + T-cell epitopes

A robust deep learning workflow to predict CD8 + T-cell epitopes

Abstract Background T-cells play a crucial role in the adaptive immune system by triggering responses against cancer cells and pathogens, while maintaining tolerance against self-antigens, which has sparked interest in the development of various T-cell-focused immunotherapies. However, the identific...

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Bibliographic Details
Main Authors: Chloe H. Lee, Jaesung Huh, Paul R. Buckley, Myeongjun Jang, Mariana Pereira Pinho, Ricardo A. Fernandes, Agne Antanaviciute, Alison Simmons, Hashem Koohy
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Genome Medicine
Subjects:
Immunogenicity
CD8 + T-cell epitopes
Deep learning
Transfer learning
Computational immunology
Epitope prediction
Online Access:https://doi.org/10.1186/s13073-023-01225-z

Internet

https://doi.org/10.1186/s13073-023-01225-z

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