Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation

Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation

Autologous, CCR5 gene-edited hematopoietic stem and progenitor cell (HSPC) transplantation is a promising strategy for achieving HIV remission. However, only a fraction of HSPCs can be edited ex vivo to provide protection against infection. To project the thresholds of CCR5-edition necessary for HIV...

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Bibliographic Details
Main Authors: E Fabian Cardozo-Ojeda, Elizabeth R Duke, Christopher W Peterson, Daniel B Reeves, Bryan T Mayer, Hans-Peter Kiem, Joshua T Schiffer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
mathematical modeling
HIV cure
pigtailed macaque
hematopoietic ΔCCR5 stem cells
autologous transplantation
nonlinear mixed-effects
Online Access:https://elifesciences.org/articles/57646

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https://elifesciences.org/articles/57646

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