Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno‐associated virus capsid and promoter

Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno‐associated virus capsid and promoter

Abstract In this report, we describe the development of a modified adeno‐associated virus (AAV) capsid and promoter for transduction of retinal ON‐bipolar cells. The bipolar cells, which are post‐synaptic to the photoreceptors, are important retinal targets for both basic and preclinical research. I...

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Bibliographic Details
Main Authors: Therese Cronin, Luk H Vandenberghe, Péter Hantz, Josephine Juttner, Andreas Reimann, Ágota–Enikő Kacsó, Rachel M Huckfeldt, Volker Busskamp, Hubertus Kohler, Pamela S Lagali, Botond Roska, Jean Bennett
Format: Article
Language:English
Published: Springer Nature 2014-08-01
Series:EMBO Molecular Medicine
Subjects:
adeno‐associated virus
capsid library
multi‐electrode array
optogenetics
promoter optimization
Online Access:https://doi.org/10.15252/emmm.201404077

Internet

https://doi.org/10.15252/emmm.201404077

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