Semaphorin3A increases M1-like microglia and retinal ganglion cell apoptosis after optic nerve injury

Semaphorin3A increases M1-like microglia and retinal ganglion cell apoptosis after optic nerve injury

Abstract Background The mechanisms leading to retinal ganglion cell (RGC) death after optic nerve injury have not been fully elucidated. Current evidence indicates that microglial activation and M1- and M2-like dynamics may be an important factor in RGC apoptosis after optic nerve crush (ONC). Semap...

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Bibliographic Details
Main Authors: Liu Yun-Jia, Chen Xi, Zhang Jie-Qiong, Zhu Jing-Yi, Lin Sen, Ye Jian
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Cell & Bioscience
Subjects:
semaphorin3A (Sema3A)
retinal ganglion cells (RGCs)
Microglia polarization, M1/M2-like
Neuroinflammation
Online Access:https://doi.org/10.1186/s13578-021-00603-7

Internet

https://doi.org/10.1186/s13578-021-00603-7

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