Drosophila CRISPR/Cas9 mutants as tools to analyse cardiac filamin function and pathogenicity of human FLNC variants

Drosophila CRISPR/Cas9 mutants as tools to analyse cardiac filamin function and pathogenicity of human FLNC variants

Filamins are large proteins with actin-binding properties. Mutations in FLNC, one of the three filamin genes in humans, have recently been implicated in dominant cardiomyopathies, but the underlying mechanisms are not well understood. Here, we aimed to use Drosophila melanogaster as a new in vivo mo...

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Bibliographic Details
Main Authors: Flavie Ader, Maria Russi, Laura Tixier-Cardoso, Estelle Jullian, Elodie Martin, Pascale Richard, Eric Villard, Veronique Monnier
Format: Article
Language:English
Published: The Company of Biologists 2022-09-01
Series:Biology Open
Subjects:
filamin
cardiomyopathy
cheerio
heart function
drosophila model
Online Access:http://bio.biologists.org/content/11/9/bio059376

Internet

http://bio.biologists.org/content/11/9/bio059376

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