TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection.

TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection.

While T cell immunity initially limits Mycobacterium tuberculosis infection, why T cell immunity fails to sterilize the infection and allows recrudescence is not clear. One hypothesis is that T cell exhaustion impairs immunity and is detrimental to the outcome of M. tuberculosis infection. Here we p...

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Bibliographic Details
Main Authors: Pushpa Jayaraman, Miye K Jacques, Chen Zhu, Katherine M Steblenko, Britni L Stowell, Asaf Madi, Ana C Anderson, Vijay K Kuchroo, Samuel M Behar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4788425?pdf=render

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http://europepmc.org/articles/PMC4788425?pdf=render

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