Functional mapping of microRNA promoters with dCas9 fused to transcriptional regulators

Functional mapping of microRNA promoters with dCas9 fused to transcriptional regulators

MicroRNAs are small non-coding RNAs that control gene expression during development, physiology, and disease. Transcription is a key factor in microRNA abundance and tissue-specific expression. Many databases predict the location of microRNA transcription start sites and promoters. However, these ca...

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Bibliographic Details
Main Authors: Pradeep Kumar, Mathilde Courtes, Céline Lemmers, Anne Le Digarcher, Ilda Coku, Arnaud Monteil, Charles Hong, Annie Varrault, Runhua Liu, Lizhong Wang, Tristan Bouschet
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Genetics
Subjects:
microRNA
CRISPRa
CRISPRi
promoter
Mest/PEG1
miR-335
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1147222/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2023.1147222/full

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