Broad-spectrum kinetic resolution of alcohols enabled by Cu–H-catalysed dehydrogenative coupling with hydrosilanes
Kinetic resolution of alcohols by silylation is an attractive method to produce enantiopure compounds, but known systems often display limited substrate scope. Here the authors report a copper catalysed enantioselective dehydrogenative silylation of alcohols that have high selectivity across a broad...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15547 |