Synaptic expression of TAR-DNA-binding protein 43 in the mouse spinal cord determined using super-resolution microscopy

Synaptic expression of TAR-DNA-binding protein 43 in the mouse spinal cord determined using super-resolution microscopy

Amyotrophic Lateral Sclerosis (ALS) is characterised by a loss of motor neurons in the brain and spinal cord that is preceded by early-stage changes in synapses that may be associated with TAR-DNA-Binding Protein 43 (TDP-43) pathology. Cellular inclusions of hyperphosphorylated TDP-43 (pTDP-43) are...

Full description

Bibliographic Details
Main Authors: Matthew J. Broadhead, Ani Ayvazian-Hancock, Katherine Doucet, Owen Kantelberg, Lesley Motherwell, Fei Zhu, Seth G. N. Grant, Mathew H. Horrocks, Gareth B. Miles
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
ALS (Amyotrophic Lateral Sclerosis)
synapse
super-resolution
TDP-43 (43 kDa TAR DNA-binding protein)
spinal cord
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1027898/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1027898/full

Similar Items