Immune mapping of human tuberculosis and sarcoidosis lung granulomas

Immune mapping of human tuberculosis and sarcoidosis lung granulomas

Tuberculosis (TB) and sarcoidosis are both granulomatous diseases. Here, we compared the immunological microenvironments of granulomas from TB and sarcoidosis patients using in situ sequencing (ISS) transcriptomic analysis and multiplexed immunolabeling of tissue sections. TB lesions consisted of la...

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Bibliographic Details
Main Authors: Berit Carow, Victoria Muliadi, Kristina Skålén, Chika Yokota, Gokul Raj Kathamuthu, Todia Pediatama Setiabudiawan, Christoph Lange, Katrin Scheu, Karoline I. Gaede, Torsten Goldmann, Ankur Pandita, Kiran Iqbal Masood, Shahid Pervez, Johan Grunewald, Zahra Hasan, Max Levin, Martin E. Rottenberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
sarcoidosis
granuloma
spatial transcriptomics
inducible bronchus associated lymphoid tissue
lung
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1332733/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1332733/full

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