The microbiota as a component of the celiac disease and non-celiac gluten sensitivity
Dietary gluten present in wheat, rye and barley induces several gastrointestinal disorders, including celiac disease and non-celiac gluten sensitivity (NCGS). Celiac disease is an immune-based enteropathy triggered by ingestion of gluten in genetically susceptible individuals resulting from the inte...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-04-01
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| Series: | Clinical Nutrition Experimental |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352939316000038 |
| _version_ | 1819133556500201472 |
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| author | Lotta Nylund Katri Kaukinen Katri Lindfors |
| author_facet | Lotta Nylund Katri Kaukinen Katri Lindfors |
| author_sort | Lotta Nylund |
| collection | DOAJ |
| description | Dietary gluten present in wheat, rye and barley induces several gastrointestinal disorders, including celiac disease and non-celiac gluten sensitivity (NCGS). Celiac disease is an immune-based enteropathy triggered by ingestion of gluten in genetically susceptible individuals resulting from the interaction between genetic and environmental factors. Although gluten has been recognized as the main environmental trigger of the disease, a specific role for the intestinal microbiota in celiac disease development has been suggested.
NCGS individuals develop adverse reactions after the exposure to gluten. Due to the similarities in clinical outcomes and the absence of diagnostic biomarkers, it is challenging to differentiate NCGS from celiac disease. The aetiology of NCGS remains unknown, although the involvement of innate immune mechanisms has been suggested. Since the influence of intestinal microbiota on immune cell homeostasis and on education of both innate and adaptive immune system is well known, the role of host-microbe interactions in the non-celiac gluten sensitivity have been hypothesized.
This review aims to summarize the current knowledge of the contribution of microbiota to the pathogenesis and/or onset of celiac disease. In addition, a brief overview of the possible role of the microbiota components on the NCGS is presented. |
| first_indexed | 2024-12-22T09:49:10Z |
| format | Article |
| id | doaj.art-e510ff5e6cf846968ed3aa5c223cf96d |
| institution | Directory Open Access Journal |
| issn | 2352-9393 |
| language | English |
| last_indexed | 2024-12-22T09:49:10Z |
| publishDate | 2016-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Experimental |
| spelling | doaj.art-e510ff5e6cf846968ed3aa5c223cf96d2022-12-21T18:30:27ZengElsevierClinical Nutrition Experimental2352-93932016-04-016C172410.1016/j.yclnex.2016.01.002The microbiota as a component of the celiac disease and non-celiac gluten sensitivityLotta Nylund0Katri Kaukinen1Katri Lindfors2Tampere Centre for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, FinlandDepartment of Internal Medicine, Tampere University Hospital, Tampere, FinlandTampere Centre for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, FinlandDietary gluten present in wheat, rye and barley induces several gastrointestinal disorders, including celiac disease and non-celiac gluten sensitivity (NCGS). Celiac disease is an immune-based enteropathy triggered by ingestion of gluten in genetically susceptible individuals resulting from the interaction between genetic and environmental factors. Although gluten has been recognized as the main environmental trigger of the disease, a specific role for the intestinal microbiota in celiac disease development has been suggested. NCGS individuals develop adverse reactions after the exposure to gluten. Due to the similarities in clinical outcomes and the absence of diagnostic biomarkers, it is challenging to differentiate NCGS from celiac disease. The aetiology of NCGS remains unknown, although the involvement of innate immune mechanisms has been suggested. Since the influence of intestinal microbiota on immune cell homeostasis and on education of both innate and adaptive immune system is well known, the role of host-microbe interactions in the non-celiac gluten sensitivity have been hypothesized. This review aims to summarize the current knowledge of the contribution of microbiota to the pathogenesis and/or onset of celiac disease. In addition, a brief overview of the possible role of the microbiota components on the NCGS is presented.http://www.sciencedirect.com/science/article/pii/S2352939316000038Celiac diseaseNon-celiac gluten sensitivityIntestinal microbiotaHost-microbe interactionsGluten-free diet |
| spellingShingle | Lotta Nylund Katri Kaukinen Katri Lindfors The microbiota as a component of the celiac disease and non-celiac gluten sensitivity Clinical Nutrition Experimental Celiac disease Non-celiac gluten sensitivity Intestinal microbiota Host-microbe interactions Gluten-free diet |
| title | The microbiota as a component of the celiac disease and non-celiac gluten sensitivity |
| title_full | The microbiota as a component of the celiac disease and non-celiac gluten sensitivity |
| title_fullStr | The microbiota as a component of the celiac disease and non-celiac gluten sensitivity |
| title_full_unstemmed | The microbiota as a component of the celiac disease and non-celiac gluten sensitivity |
| title_short | The microbiota as a component of the celiac disease and non-celiac gluten sensitivity |
| title_sort | microbiota as a component of the celiac disease and non celiac gluten sensitivity |
| topic | Celiac disease Non-celiac gluten sensitivity Intestinal microbiota Host-microbe interactions Gluten-free diet |
| url | http://www.sciencedirect.com/science/article/pii/S2352939316000038 |
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