Is Poor Lithium Response in Individuals with Bipolar Disorder Associated with Increased Degradation of Tryptophan along the Kynurenine Pathway? Results of an Exploratory Study

Is Poor Lithium Response in Individuals with Bipolar Disorder Associated with Increased Degradation of Tryptophan along the Kynurenine Pathway? Results of an Exploratory Study

Bipolar disorder is associated with an inflammation-triggered elevated catabolism of tryptophan to the kynurenine pathway, which impacts psychiatric symptoms and outcomes. The data indicate that lithium exerts anti-inflammatory effects by inhibiting indoleamine-2,3-dioxygenase (IDO)-1 activity. This...

Full description

Bibliographic Details
Main Authors: Frederike T. Fellendorf, Mirko Manchia, Alessio Squassina, Claudia Pisanu, Stefano Dall’Acqua, Stefania Sut, Sofia Nasini, Donatella Congiu, Eva Z. Reininghaus, Mario Garzilli, Beatrice Guiso, Federico Suprani, Pasquale Paribello, Vittoria Pulcinelli, Maria Novella Iaselli, Ilaria Pinna, Giulia Somaini, Laura Arru, Carolina Corrias, Federica Pinna, Bernardo Carpiniello, Stefano Comai
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Journal of Clinical Medicine
Subjects:
bipolar disorder
tryptophan
kynurenine
indoleamine 2,3 dioxygenase (IDO)
lithium response
Alda scale
Online Access:https://www.mdpi.com/2077-0383/11/9/2517

Internet

https://www.mdpi.com/2077-0383/11/9/2517

Similar Items