A cleavable peptide adapter augments the activity of targeted toxins in combination with the glycosidic endosomal escape enhancer SO1861

A cleavable peptide adapter augments the activity of targeted toxins in combination with the glycosidic endosomal escape enhancer SO1861

Abstract Background Treatment with tumor-targeted toxins attempts to overcome the disadvantages of conventional cancer therapies by directing a drug’s cytotoxic effect specifically towards cancer cells. However, success with targeted toxins has been hampered as the constructs commonly remain bound t...

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Bibliographic Details
Main Authors: Finn J. Schulze, Mazdak Asadian-Birjand, Michael Pradela, Nicole Niesler, Gregor Nagel, Hendrik Fuchs
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Biotechnology
Subjects:
Molecular adapter
Glycosylated triterpenoid
Endosomal escape
Drug delivery
Cancer treatment
Epidermal growth factor
Online Access:https://doi.org/10.1186/s12896-024-00854-5

Internet

https://doi.org/10.1186/s12896-024-00854-5

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