Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice

Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice

Summary: The E3 ubiquitin ligase Ube3a is biallelically expressed in neural progenitors and glial cells, suggesting that UBE3A gain-of-function mutations might cause neurodevelopmental disorders irrespective of parent of origin. Here, we engineered a mouse line that harbors an autism-linked UBE3AT48...

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Bibliographic Details
Main Authors: Lei Xing, Jeremy M. Simon, Travis S. Ptacek, Jason J. Yi, Lipin Loo, Hanqian Mao, Justin M. Wolter, Eric S. McCoy, Smita R. Paranjape, Bonnie Taylor-Blake, Mark J. Zylka
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723007179

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http://www.sciencedirect.com/science/article/pii/S2211124723007179

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