Inhibition of colon cancer K-RasG13D mutation reduces cancer cell proliferation but promotes stemness and inflammation via RAS/ERK pathway

Inhibition of colon cancer K-RasG13D mutation reduces cancer cell proliferation but promotes stemness and inflammation via RAS/ERK pathway

K-Ras is a well-studied oncogene, and its mutation is frequently found in epithelial cancers like pancreas, lung, and colorectal cancers. Cancer cells harboring K-Ras mutations are difficult to treat due to the drug resistance and metastasis properties. Cancer stem cells (CSCs) are believed the majo...

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Bibliographic Details
Main Authors: Yan Qi, Hong Zou, XiaoHui Zhao, Joanna Kapeleris, Michael Monteiro, Feng Li, Zhi Ping Xu, Yizhen Deng, Yanheng Wu, Ying Tang, Wenyi Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
K-RasG13D mutation
colon cancer
cancer stem cells
tumor spheroid
ERK pathway
PI3K/Akt pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.996053/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.996053/full

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