<i>Drosophila</i> as a Model of Unconventional Translation in Spinocerebellar Ataxia Type 3

<i>Drosophila</i> as a Model of Unconventional Translation in Spinocerebellar Ataxia Type 3

RNA toxicity contributes to diseases caused by anomalous nucleotide repeat expansions. Recent work demonstrated RNA-based toxicity from repeat-associated, non-AUG-initiated translation (RAN translation). RAN translation occurs around long nucleotide repeats that form hairpin loops, allowing for tran...

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Bibliographic Details
Main Authors: Sean L. Johnson, Matthew V. Prifti, Alyson Sujkowski, Kozeta Libohova, Jessica R. Blount, Luke Hong, Wei-Ling Tsou, Sokol V. Todi
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
ataxin-3
Gal4-UAS
glia
Machado–Joseph disease
neuron
neurodegeneration
Online Access:https://www.mdpi.com/2073-4409/11/7/1223

Internet

https://www.mdpi.com/2073-4409/11/7/1223

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