1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione
A simple, fast and cost-effective three-step synthesis of 1-methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione has been developed. The reactions described herein proceed readily, with high yields and no further purification. Therefore, the proposed method, with an overall yield of 60%, offers a fac...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Molbank |
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| Online Access: | https://www.mdpi.com/1422-8599/2021/2/M1228 |
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| author | Vasiliki Pardali Sotirios Katsamakas Erofili Giannakopoulou Grigoris Zoidis |
| author_facet | Vasiliki Pardali Sotirios Katsamakas Erofili Giannakopoulou Grigoris Zoidis |
| author_sort | Vasiliki Pardali |
| collection | DOAJ |
| description | A simple, fast and cost-effective three-step synthesis of 1-methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione has been developed. The reactions described herein proceed readily, with high yields and no further purification. Therefore, the proposed method, with an overall yield of 60%, offers a facile pathway to the synthesis of N-1 monosubstituted spiro carbocyclic imidazolidine-2,4-diones (hydantoins), which constitute a privileged class of heterocyclic scaffolds with pharmacological interest. |
| first_indexed | 2024-03-10T10:42:26Z |
| format | Article |
| id | doaj.art-e5213cea7cb64ad792399638978a8839 |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-03-10T10:42:26Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-e5213cea7cb64ad792399638978a88392023-11-21T22:52:58ZengMDPI AGMolbank1422-85992021-06-0120212M122810.3390/M12281-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dioneVasiliki Pardali0Sotirios Katsamakas1Erofili Giannakopoulou2Grigoris Zoidis3Department of Pharmacy, Division of Pharmaceutical Chemistry, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceDepartment of Pharmacy, Division of Pharmaceutical Chemistry, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceDepartment of Pharmacy, Division of Pharmaceutical Chemistry, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceDepartment of Pharmacy, Division of Pharmaceutical Chemistry, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceA simple, fast and cost-effective three-step synthesis of 1-methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione has been developed. The reactions described herein proceed readily, with high yields and no further purification. Therefore, the proposed method, with an overall yield of 60%, offers a facile pathway to the synthesis of N-1 monosubstituted spiro carbocyclic imidazolidine-2,4-diones (hydantoins), which constitute a privileged class of heterocyclic scaffolds with pharmacological interest.https://www.mdpi.com/1422-8599/2021/2/M1228carbocyclic hydantoinsN-1 substituted hydantoinspiro hydantoinsimidazolidine-2,4-dionesDFT calculationsstereochemistry |
| spellingShingle | Vasiliki Pardali Sotirios Katsamakas Erofili Giannakopoulou Grigoris Zoidis 1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione Molbank carbocyclic hydantoins N-1 substituted hydantoin spiro hydantoins imidazolidine-2,4-diones DFT calculations stereochemistry |
| title | 1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione |
| title_full | 1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione |
| title_fullStr | 1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione |
| title_full_unstemmed | 1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione |
| title_short | 1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione |
| title_sort | 1 methyl 8 phenyl 1 3 diazaspiro 4 5 decane 2 4 dione |
| topic | carbocyclic hydantoins N-1 substituted hydantoin spiro hydantoins imidazolidine-2,4-diones DFT calculations stereochemistry |
| url | https://www.mdpi.com/1422-8599/2021/2/M1228 |
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