The UBC9/SUMO pathway affects E-cadherin cleavage in HPV-positive head and neck cancer

The UBC9/SUMO pathway affects E-cadherin cleavage in HPV-positive head and neck cancer

Functional loss of E-cadherin is frequent during tumor progression and occurs through a variety of mechanisms, including proteolytic cleavage. E-cadherin downregulation leads to the conversion of a more malignant phenotype promoting Epithelial to Mesenchymal Transition (EMT). The UBC9/SUMO pathway h...

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Bibliographic Details
Main Authors: Maria Elisa Sabatini, Micaela Compagnoni, Fausto Maffini, Claudia Miccolo, Fabio Pagni, Mariano Lombardi, Virginia Brambilla, Daniela Lepanto, Marta Tagliabue, Mohssen Ansarin, Simona Citro, Susanna Chiocca
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
head and neck cancer
head and neck squamous cell carcinoma
HPV
SUMO
Ubc9
E-cadherin
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.940449/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.940449/full

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