Mono-Alkylated Ligands Based on Pyrazole and Triazole Derivatives Tested Against Fusarium oxysporum f. sp. albedinis: Synthesis, Characterization, DFT, and Phytase Binding Site Identification Using Blind Docking/Virtual Screening for Potent Fophy Inhibitors

Mono-Alkylated Ligands Based on Pyrazole and Triazole Derivatives Tested Against Fusarium oxysporum f. sp. albedinis: Synthesis, Characterization, DFT, and Phytase Binding Site Identification Using Blind Docking/Virtual Screening for Potent Fophy Inhibitors

Twelve recent compounds, incorporating several heterocyclic moieties such as pyrazole, thiazole, triazole, and benzotriazole, made in excellent yield up to 37–99.6%. They were tested against Fusarium oxysporum f. sp. albedinis fungi (Bayoud disease), where the best results are for compounds 2, 4, an...

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Bibliographic Details
Main Authors: Yassine Kaddouri, Farid Abrigach, Sabir Ouahhoud, Redouane Benabbes, Mohamed El Kodadi, Ali Alsalme, Nabil Al-Zaqri, Ismail Warad, Rachid Touzani
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Chemistry
Subjects:
pyrazole
triazole
Fusarium oxysporum
antifungal
DFT
docking
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2020.559262/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2020.559262/full

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